Activating Compound | Comment | Organism | Structure |
---|---|---|---|
colistin | significant stimulation of purified elastase and elastase activity in sputum samples, able to reverse inhibition by heparin | Homo sapiens | |
erythromycin | significant stimulation of purified elastase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-antitrypsin | very potent inhibitor, complete inhibition at nanomolar concentrations, colistin is unable to reverse inhibition | Homo sapiens | |
ceftazidime | slight inhibition of purified elastase | Homo sapiens | |
gentamycin | slight inhibition of purified elastase | Homo sapiens | |
heparin | strong inhibition, partly reversible by addition of colistin | Homo sapiens | |
N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone | complete inhibition at low micromolar concentrations, colistin is unable to reverse the complete inhibition with 0.005 mM but able to reverse the partial inhibition with 0.0005 mM N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone | Homo sapiens | |
tobramycin | slight inhibition of purified elastase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | Homo sapiens | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | ? | protein cleaved at at least one location | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with cystic fibrosis | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
sputum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | Homo sapiens | ? | protein cleaved at at least one location | ? | |
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? |