Inhibitors | Comment | Organism | Structure |
---|---|---|---|
heparin | tight-binding non-competitive inhibitor, 90% inhibition at 0.5 ng/ml, higher chain length of oligosaccharides causes stronger inhibition, desulfated heparins lack inhibitory potential, ionic strength above 0.5 abolishes the inhibitory capacity of heparin | Homo sapiens | |
heparin | tight-binding non-competitive inhibitor, 90% inhibition at 0.5 ng/ml, higher chain length of oligosaccharides causes stronger inhibition, desulfated heparins lack inhibitory potential, ionic strength above 0.5 abolishes the inhibitory capacity of heparin | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.5 | - |
succinyl-Ala-Ala-NH-4-nitroanilide | pH 8.0, 37°C | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | Homo sapiens | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells also might be damaged, involved in the onset of emphysema and rheumatoid arthritis | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | Rattus norvegicus | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the onset of emphysema and rheumatoid arthritis | ? | protein cleaved at at least one location | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | pleural exudates | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
Elastin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells also might be damaged, involved in the onset of emphysema and rheumatoid arthritis | Homo sapiens | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the onset of emphysema and rheumatoid arthritis | Rattus norvegicus | ? | protein cleaved at at least one location | ? | |
succinyl-Ala-Ala-NH-4-nitroanilide + H2O | - |
Homo sapiens | succinyl-Ala-Ala-NH2 + 4-nitroaniline | - |
? | |
succinyl-Ala-Ala-NH-4-nitroanilide + H2O | - |
Rattus norvegicus | succinyl-Ala-Ala-NH2 + 4-nitroaniline | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
heparin | 8 disaccharide units, pH 8.0, 37°C | Rattus norvegicus | |
0.023 | - |
heparin | 5 disaccharide units, pH 8.0, 37°C | Rattus norvegicus | |
0.1 | - |
heparin | 2 disaccharide units, pH 8.0, 37°C | Rattus norvegicus |