Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid | SC-39026 | Cricetulus griseus | |
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid | SC-39026, reversible non-competitive inhibition at low concentrations (0.0005-0.00125 mM), mixed type inhibition at higher concentrations | Homo sapiens | |
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid | SC-39026 | Oryctolagus cuniculus | |
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid | SC-39026 | Rattus norvegicus | |
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid | SC-39026 | Sus scrofa | |
alpha-1-antitrypsin | - |
Oryctolagus cuniculus | |
methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone | - |
Homo sapiens | |
methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone | - |
Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | Cricetulus griseus | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | Homo sapiens | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | Rattus norvegicus | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | Sus scrofa | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | Oryctolagus cuniculus | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | ? | protein cleaved at at least one location | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | - |
Cricetulus griseus | - |
leukocyte | - |
Homo sapiens | - |
leukocyte | - |
Rattus norvegicus | - |
leukocyte | - |
Sus scrofa | - |
leukocyte | - |
Oryctolagus cuniculus | - |
neutrophil | - |
Cricetulus griseus | - |
neutrophil | - |
Homo sapiens | - |
neutrophil | - |
Rattus norvegicus | - |
neutrophil | - |
Sus scrofa | - |
neutrophil | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | - |
Cricetulus griseus | ? | - |
? | |
Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
Elastin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Elastin + H2O | - |
Sus scrofa | ? | - |
? | |
Elastin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | Cricetulus griseus | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | Homo sapiens | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | Rattus norvegicus | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | Sus scrofa | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, involved in the etiology of emphysema, rheumatoid arthritis, psoriasis, and adult respiratory distress syndrome | Oryctolagus cuniculus | ? | protein cleaved at at least one location | ? | |
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Cricetulus griseus | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Rattus norvegicus | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Sus scrofa | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Oryctolagus cuniculus | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid | pH 8.0, 30°C | Homo sapiens |