Literature summary for 3.4.21.37 extracted from

Baici, A.; Pelloso, R.; Horler, D.
The kinetic mechanism of inhibition of human leukocyte elastase by MR889, a new cyclic thiolic compound (1990), Biochem. Pharmacol., 39, 919-924.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(thiophen-2-ylcarbonylthio)-N-(2-oxo-2,3,4,5-tetrahydrothiophen-3-yl)propionamide	reversible, slow-binding, fully competitive	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000127	-	2-(thiophen-2-ylcarbonylthio)-N-(2-oxo-2,3,4,5-tetrahydrothiophen-3-yl)propionamide	pH 7.4, 37°C, pre-steady-state analysis	Homo sapiens
0.00138	-	2-(thiophen-2-ylcarbonylthio)-N-(2-oxo-2,3,4,5-tetrahydrothiophen-3-yl)propionamide	pH 7.4, 37°C, graphic analysis	Homo sapiens

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Release 2023.1 (January 2023)