Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.37 extracted from

  • Junger, W.G.; Hallström, S.; Liu, F.C.; Redl, H.; Schlag, G.
    The enzymatic and release characteristics of sheep neutrophil elastase: a comparison with human neutrophil elastase (1992), Biol. Chem. Hoppe-Seyler, 373, 691-698.
    View publication on PubMed
Search for more literature for 3.4.21.37

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.21
-
 methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide pH 7.4, 37°C Homo sapiens
1.82
-
 methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide pH 7.4, 37°C Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens elastase in contrast to human elastase, may play a minor role in mediating tissue damage and organ failure ?
-
 ?
additional information Ovis aries elastase in contrast to human elastase, may play a minor role in mediating tissue damage and organ failure ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Ovis aries
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Ovis aries ?
-
 ?
additional information elastase in contrast to human elastase, may play a minor role in mediating tissue damage and organ failure Homo sapiens ?
-
 ?
additional information elastase in contrast to human elastase, may play a minor role in mediating tissue damage and organ failure Ovis aries ?
-
 ?
oxidized B chain of insulin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? 3 protein bands of 22000 Da, 24000 Da, and 25000 Da are detected by SDS-PAGE Ovis aries
? 3 polypeptides of 27500 Da, 28000 Da and 31000 Da are detected by SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
16
-
 methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide pH 7.4, 37°C Ovis aries
23
-
 methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide pH 7.4, 37°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Homo sapiens