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Literature summary for 3.4.21.37 extracted from
- Leukocyte elastase (1981), Methods Enzymol., 80, 581-588.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alpha1-proteinase inhibitor | - |
Homo sapiens | |
| alpha2-Macroglobulin | - |
Homo sapiens | |
| elasnin | - |
Homo sapiens |  |
| Elastatinal | - |
Homo sapiens | |
| Kunitz inhibitor | - |
Homo sapiens | |
| long-chain fatty acids | - |
Homo sapiens | |
| methoxysuccinyl-Ala-Ala-Pro-Val-CH2Cl | - |
Homo sapiens | |
| ovomucoid | turkey ovomucoid | Homo sapiens | |
| phenylmethylsulfonyl fluoride | - |
Homo sapiens | |
| polysaccharide sulfates | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| azurophil granule | - |
Homo sapiens | 42582 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme may be involved in a number of important disease states. Including the pulmonary emphysema associated with a hereditary deficiency of alpha1-proteinase inhibitor | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
| Equus caballus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | neutrophil leukocytes | Homo sapiens | - |
| polymorphonuclear cell | - |
Homo sapiens | - |
| polymorphonuclear cell | - |
Sus scrofa | - |
| polymorphonuclear cell | - |
Oryctolagus cuniculus | - |
| polymorphonuclear cell | - |
Canis lupus familiaris | - |
| polymorphonuclear cell | - |
Equus caballus | - |
| spleen | - |
Homo sapiens | - |
| synovial membrane | - |
Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 0.5 M pyridine acetate buffer, pH 5.3, stable for years | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Cartilage proteoglycan + H2O | - |
Homo sapiens | ? | - |
? | |
| Collagen + H2O | type I, II, III, and IV | Homo sapiens | ? | - |
? | |
| Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| methoxysuccinyl-Ala-Ala-Pro-Val-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | methoxysuccinyl-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin | - |
? | |
| additional information | the enzyme may be involved in a number of important disease states. Including the pulmonary emphysema associated with a hereditary deficiency of alpha1-proteinase inhibitor | Homo sapiens | ? | - |
? | |
| oxidized B chain of insulin + H2O | - |
Homo sapiens | ? | - |
? | |
| tert-butyloxycarbonyl-Ala-4-nitrophenyl ester + H2O | - |
Homo sapiens | tert-butyloxycarbonyl-Ala + 4-nitrophenol | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | - |
9.15 | 8.77 |
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Release 2023.1 (January 2023)
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