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Literature summary for 3.4.21.35 extracted from

  • Magnen, M.; Gueugnon, F.; Petit-Courty, A.; Baranek, T.; Sizaret, D.; Brewah, Y.A.; Humbles, A.A.; Si-Tahar, M.; Courty, Y.
    Tissue kallikrein (KLK1) regulates alveolar macrophage apoptosis early in influenza virus infection (2019), Am. J. Physiol. Lung Cell Mol. Physiol., 316, L1127-L1140 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
low-molecular-weight kininogen + H2O Mus musculus
-
 kallidin + kinin
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P15947
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar macrophage
-
 Mus musculus
-
bronchoalveolar lavage fluid
-
 Mus musculus
-
lung
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
low-molecular-weight kininogen + H2O
-
 Mus musculus kallidin + kinin
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein 1
-
 Mus musculus
KLK1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme levels in lung tissue and in bronchoalveolar lavage fluid increase substantially during infection with influenza H3N2 virus up

General Information

General Information Comment Organism
malfunction enzyme inhibition accelerates the initial virus-induced apoptotic depletion of alveolar macrophages Mus musculus
physiological function the enzyme regulates alveolar macrophage apoptosis early in influenza virus infection Mus musculus