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Literature summary for 3.4.21.35 extracted from
- Structure of plasma and tissue kallikreins (2013), Thromb. Haemost., 110, 423-433.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
Abz-GFSPFRSSRI-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens |  |
| 0.00036 | - |
Abz-GFSPFRSLRI-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0007 | - |
Abz-MISLMKRP-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0015 | - |
Abz-FRSSR-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 0.009 | - |
Abz-MISLMKLP-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| low-molecular-weight kininogen + H2O | Homo sapiens | - |
GMISLM + KRPPGFSPFR + SSRIG | KRPPGFSPFR is kallidin | ? | |
| semenogelin I + H2O | Homo sapiens | - |
KGISSQY + SNTE | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P06870 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Abz-FRSSR-Q-EDDnp + H2O | - |
Homo sapiens | Abz-FR + SSR-Q-EDDnp | - |
? | |
| Abz-GFSPFRSLRI-Q-EDDnp + H2O | - |
Homo sapiens | Abz-GFSPFR + SLRI-Q-EDDnp | - |
? | |
| Abz-GFSPFRSSRI-Q-EDDnp + H2O | - |
Homo sapiens | Abz-GFSPFR + SSRI-Q-EDDnp | - |
? | |
| Abz-MISLMKLP-Q-EDDnp + H2O | - |
Homo sapiens | Abz-MISLM + KLP-Q-EDDnp | - |
? | |
| Abz-MISLMKRP-Q-EDDnp + H2O | - |
Homo sapiens | Abz-MISLM + KRP-Q-EDDnp | - |
? | |
| low-molecular-weight kininogen + H2O | - |
Homo sapiens | GMISLM + KRPPGFSPFR + SSRIG | KRPPGFSPFR is kallidin | ? | |
| additional information | KLK1 shows substrate specificity with Tyr and Arg preferred at P1 and Ser at P1' | Homo sapiens | ? | - |
? | |
| semenogelin I + H2O | - |
Homo sapiens | KGISSQY + SNTE | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EMSP1 | - |
Homo sapiens |
| HSCTE | - |
Homo sapiens |
| KLK-L1 protein | - |
Homo sapiens |
| KLK-L2 protein | - |
Homo sapiens |
| KLK1 | isoform | Homo sapiens |
| KLK3 | isoform | Homo sapiens |
| KLK4 | isoform | Homo sapiens |
| KLK5 | isoform | Homo sapiens |
| KLK6 | isoform | Homo sapiens |
| neurosin | - |
Homo sapiens |
| pancreatic/renal kallikrein | - |
Homo sapiens |
| Prk | - |
Homo sapiens |
| prokallikrein | zymogen | Homo sapiens |
| prostase | - |
Homo sapiens |
| prostate specific antigen | - |
Homo sapiens |
| protease M | - |
Homo sapiens |
| PSA | - |
Homo sapiens |
| zyme | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
Abz-MISLMKLP-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 0.33 | - |
Abz-MISLMKRP-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 1.6 | - |
Abz-FRSSR-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 4.6 | - |
Abz-GFSPFRSLRI-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 17.7 | - |
Abz-GFSPFRSSRI-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2 | - |
Abz-MISLMKLP-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 471 | - |
Abz-MISLMKRP-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 1067 | - |
Abz-FRSSR-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 12780 | - |
Abz-GFSPFRSLRI-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
| 88500 | - |
Abz-GFSPFRSSRI-Q-EDDnp | pH and temperature not specified in the publication | Homo sapiens | |
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