Literature summary for 3.4.21.35 extracted from

Yiu, W.H.; Wong, D.W.; Chan, L.Y.; Leung, J.C.; Chan, K.W.; Lan, H.Y.; Lai, K.N.; Tang, S.C.
Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells (2014), PLoS One, 9, e88894.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
KLK1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	tissue kallikrein (KLK1) expression is up-regulated in human diabetic kidney tissue and induced by high glucose in human proximal tubular epithelial cells	up

General Information

General Information	Comment	Organism
malfunction	molecular knockdown of endogenous KLK1 expression attenuates advanced glycation end-products-induced interleukin-8 and intercellular adhesion molecule-1 productions in vitro	Homo sapiens
physiological function	up-regulation of KLK1 in tubular epithelial cells may mediate pro-inflammatory pathway and protease-activated receptor activation during diabetic nephropathy	Homo sapiens

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Release 2023.1 (January 2023)