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Literature summary for 3.4.21.35 extracted from

  • Fukuhara, J.; Noda, K.; Murata, M.; Namba, S.; Kinoshita, S.; Dong, Z.; Ando, R.; Lennikov, A.; Kanda, A.; Ishida, S.
    Tissue kallikrein attenuates choroidal neovascularization via cleavage of vascular endothelial growth factor (2013), Invest. Ophthalmol. Vis. Sci., 54, 274-279.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vascular endothelial growth factor 164 + H2O Rattus norvegicus
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
urine
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vascular endothelial growth factor 164 + H2O
-
 Rattus norvegicus ?
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 ?

General Information

General Information Comment Organism
physiological function tissue kallikrein treatment significantly reduces monocyte chemoattractant protein-1, intercellular adhesion molecule-1, and interleukin-6 levels in retinal pigment epithelium-choroid complexes. Tissue kallikrein exhibits antiangiogenic properties by cleaving vascular endothelial growth factor 164 in a laser-induced choroidal neovascularization model Rattus norvegicus