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Literature summary for 3.4.21.35 extracted from
- Angiogenesis in cervical cancer is mediated by HeLa metabolites through endothelial cell tissue kallikrein (2009), Oncol. Rep., 22, 285-293.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | pre-treatment with tissue kallikrein inhibitors and/or anti-angiogenic therapies may prove to benefit future cervical cancer patients | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
| HUVEC cell | - |
Homo sapiens | - |
| salivary gland | duct cell | Homo sapiens | - |
| submandibular gland | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tissue kallikrein | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | in an endothelial-cervical carcinoma conditioned-medium model, HeLa metabolites cause a dramatic decrease in endothelial cellular tissue kallikrein and a concomitant proliferation of endothelial cells | down |
| Homo sapiens | presence of tissue kallikrein in HeLa cells and in angiogenic HUVECs. In the submandibular gland control tissue, positive tissue kallikrein staining within the ductal epithelial gland. On conditioned media a dose-dependent increase of tissue kallikrein. In challenged endothelial cells with metabolites from cervical cancer cells, the reduction in cellular tissue kallikrein is associated with a concomitant increase in tissue kallikrein within the media | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | tumour-induced, vascular-derived tissue kallikrein that surrounds angiogenic endothelial cells likely aids in stromal remodelling to allow angiogenesis and the release of contributing co-factors, contributes to neo-vasculature invasiveness and produces a tempero-spatial chemotactic message that may be recognised by cell signaling systems | Homo sapiens |
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