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Literature summary for 3.4.21.35 extracted from

  • Gao, L.; Smith, R.S.; Chen, L.M.; Chai, K.X.; Chao, L.; Chao, J.
    Tissue kallikrein promotes prostate cancer cell migration and invasion via protease-activated receptor-1-dependent signaling pathway (2010), Biol. Chem., 391, 803-812.
    View publication on PubMed
Search for more literature for 3.4.21.35

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin blocks increase of DU145 cell migration and invasion by tissue kallikrein Rattus norvegicus
icatibant minimally affects increase of DU145 cell migration and invasion by tissue kallikrein Rattus norvegicus
additional information kinin has little effect on increase of DU145 cell migration and invasion by tissue kallikrein. Tissue kallikrein-induced cell migration and invasion are abolished by inhibition of PAR1 using a pharmacological inhibitor or RNA interference. The effect of tissue kallikrein on cell migration and invasion are also blocked by inhibitors of protein kinase C, c-Src, matrix metalloproteinase, EGFR and extracellular signal-regulated kinase Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 x * 35000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by affinity column chromatography Homo sapiens
by affinity column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
salivary gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Val-Leu-Arg-4-nitroanilide + H2O
-
 Rattus norvegicus D-Val-Leu-Arg + 4-nitroaniline
-
 ?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
tissue kallikrein
-
 Homo sapiens
tissue kallikrein
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function purified tissue kallikrein promotes DU145 prostate cancer cell migration in a similar manner than rat tissue kallikrein Homo sapiens
physiological function tissue kallikrein promotes DU145 prostate cancer cell migration in a concentration-dependent manner, but has no effect on A549 lung cancer cells. Tissue kallikrein stimulates DU145 cell proliferation through activation of the kinin B2 receptor, but not PAR1 and EGFR activation. Tissue kallikrein promotes migration and invasion of DU145 cells through PAR1-PKC-Src-MMP activation and EGFR-ERK transactivation. Tissue kallikrein stimulates ERK activation through EGFR transactivation. Differential signaling pathways mediated by tissue kallikrein in promoting prostate cancer cell migration and invasion via PAR1 activation, and proliferation via kinin B2 receptor stimulation. Stimulates ERK phosphorylation Rattus norvegicus