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Literature summary for 3.4.21.35 extracted from

  • Casalino-Matsuda, S.M.; Monzon, M.E.; Conner, G.E.; Salathe, M.; Forteza, R.M.
    Role of hyaluronan and reactive oxygen species in tissue kallikrein-mediated epidermal growth factor receptor activation in human airways (2004), J. Biol. Chem., 279, 21606-21616.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens tissue kallikrein plays an important role in the airways by processing the pro-form of the epidermal growth factor to mature epidermal growth factor in airway submucosal gland cells. The activity of tissue kallikrein is regulated by hyaluronan. Tissue kallikrein is inhibited in the presence of native hyaluronan in the airway and in the submucosal gland duct. Hyaluronan depolymerization is expected to cause activation of tissue kallikrein, release of epidermal growth factor and signaling of epidermal growth factor receptor and to lead to hypertrophy of tracheal submucosal gland cells and hyperplasia as well as mucus hypersecretion with subsequent airflow obstruction ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-Val-Leu-Arg-p-nitroanilide + H2O
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 Homo sapiens DL-Val-Leu-Arg + p-nitroaniline
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additional information tissue kallikrein plays an important role in the airways by processing the pro-form of the epidermal growth factor to mature epidermal growth factor in airway submucosal gland cells. The activity of tissue kallikrein is regulated by hyaluronan. Tissue kallikrein is inhibited in the presence of native hyaluronan in the airway and in the submucosal gland duct. Hyaluronan depolymerization is expected to cause activation of tissue kallikrein, release of epidermal growth factor and signaling of epidermal growth factor receptor and to lead to hypertrophy of tracheal submucosal gland cells and hyperplasia as well as mucus hypersecretion with subsequent airflow obstruction Homo sapiens ?
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