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Literature summary for 3.4.21.35 extracted from

  • Fogaca, S.E.; Melo, R.L.; Pimenta, D.C.; Hosoi, K.; Juliano, L.; Juliano, M.A.
    Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins (2004), Biochem. J., 380, 775-781.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.35

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00017
-
 o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
0.00018
-
 D-Pro-Phe-Arg-4-methylcoumarin-7-amide 37°C, pH 8.5 Mus musculus
0.0002
-
 o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
0.00024
-
 o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
0.00033
-
 o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
0.00077
-
 o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
0.00096
-
 o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
0.001
-
 D-Pro-Phe-Phe-4-methylcoumarin-7-amide 37°C, pH 8.5 Rattus norvegicus
0.00147
-
 o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
0.0015
-
 D-Pro-Phe-Arg-4-methylcoumarin-7-amide 37°C, pH 8.5 Rattus norvegicus
0.0021
-
 o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Homo sapiens
0.00223
-
 o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
0.0024
-
 o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
0.00251
-
 o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
0.0027
-
 D-Pro-Phe-Phe-4-methylcoumarin-7-amide 37°C, pH 8.5 Mus musculus
0.003
-
 o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
0.0031
-
 D-Pro-Phe-Arg-4-methylcoumarin-7-amide 37°C, pH 8.5 Homo sapiens
0.00616
-
 o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
0.00735
-
 o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
 Homo sapiens
0.07
-
 D-Pro-Phe-Phe-4-methylcoumarin-7-amide 37°C, pH 8.5 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Pro-Phe-Arg-4-methylcoumarin-7-amide + H2O
-
 Mus musculus ?
-
 ?
D-Pro-Phe-Arg-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens ?
-
 ?
D-Pro-Phe-Arg-4-methylcoumarin-7-amide + H2O
-
 Rattus norvegicus ?
-
 ?
D-Pro-Phe-Phe-4-methylcoumarin-7-amide + H2O
-
 Mus musculus ?
-
 ?
D-Pro-Phe-Phe-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens ?
-
 ?
D-Pro-Phe-Phe-4-methylcoumarin-7-amide + H2O
-
 Rattus norvegicus ?
-
 ?
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol + H2O preferentially hydrolyzed at Phe-Arg bond compared with Phe-Arg Mus musculus o-aminobenzoyl-GFSPFR + APRVQ-ethylenediamine 2,4-dinitrophenol + o-aminobenzoyl-GFSPF + RAPRVQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol + H2O preferentially hydrolyzed at Phe-Arg bond compared with Phe-Arg Homo sapiens o-aminobenzoyl-GFSPFR + APRVQ-ethylenediamine 2,4-dinitrophenol + o-aminobenzoyl-GFSPF + RAPRVQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol + H2O preferentially hydrolyzed at Phe-Arg bond compared with Phe-Arg Rattus norvegicus o-aminobenzoyl-GFSPFR + APRVQ-ethylenediamine 2,4-dinitrophenol + o-aminobenzoyl-GFSPF + RAPRVQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
-
 Mus musculus o-aminobenzoyl-GFSPFR + SVTVQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
-
 Homo sapiens o-aminobenzoyl-GFSPFR + SVTVQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O
-
 Rattus norvegicus o-aminobenzoyl-GFSPFR + SVTVQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-MTEMARRPPGFSPFRSVTVQ-NH2 + H2O
-
 Mus musculus o-aminobenzoyl-MTEMAR + RPPGFSPFR + SVTVQ-NH2 RPPGFSPFR is bradykinin ?
o-aminobenzoyl-MTEMARRPPGFSPFRSVTVQ-NH2 + H2O
-
 Homo sapiens o-aminobenzoyl-MTEMAR + RPPGFSPFR + SVTVQ-NH2 RPPGFSPFR is bradykinin ?
o-aminobenzoyl-MTEMARRPPGFSPFRSVTVQ-NH2 + H2O
-
 Rattus norvegicus o-aminobenzoyl-MTEMAR + RPPGFSPFR + SVTVQ-NH2 RPPGFSPFR is bradykinin ?
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol + H2O
-
 Mus musculus o-aminobenzoyl-MTEMAR + RPQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol + H2O
-
 Homo sapiens o-aminobenzoyl-MTEMAR + RPQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol + H2O
-
 Rattus norvegicus o-aminobenzoyl-MTEMAR + RPQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-MTSVIRRPPGFSPFRAPRV-NH2 + H2O preferential hydrolysis of Phe-Arg compared with Arg-Ala bond, preferential release of des[Arg9] bradykinin Homo sapiens des[Arg9] bradykinin + ?
-
 ?
o-aminobenzoyl-MTSVIRRPPGFSPFRAPRV-NH2 + H2O
-
 Mus musculus o-aminobenzoyl-MTSVIR + RPPGFSPFR + APRV-NH2 RPPGFSPFR is bradykinin ?
o-aminobenzoyl-MTSVIRRPPGFSPFRAPRV-NH2 + H2O
-
 Rattus norvegicus o-aminobenzoyl-MTSVIR + RPPGFSPFR + APRV-NH2 RPPGFSPFR is bradykinin ?
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol + H2O slow hydrolysis Mus musculus o-aminobenzoyl-MTSVIR + RPQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol + H2O slow hydrolysis Homo sapiens o-aminobenzoyl-MTSVIR + RPQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol + H2O slow hydrolysis Rattus norvegicus o-aminobenzoyl-MTSVIR + RPQ-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-Phe-Arg-Arg--ethylenediamine 2,4-dinitrophenol + H2O slow hydrolysis Homo sapiens o-aminobenzoyl-Phe-Arg + Arg-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol + H2O slow hydrolysis Mus musculus o-aminobenzoyl-Phe-Arg + Arg-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol + H2O slow hydrolysis Rattus norvegicus o-aminobenzoyl-Phe-Arg + Arg-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O slow hydrolysis Mus musculus o-aminobenzoyl-Phe-Arg + Lys-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O slow hydrolysis Homo sapiens o-aminobenzoyl-Phe-Arg + Lys-ethylenediamine 2,4-dinitrophenol
-
 ?
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol + H2O slow hydrolysis Rattus norvegicus o-aminobenzoyl-Phe-Arg + Lys-ethylenediamine 2,4-dinitrophenol
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
0.05
-
 D-Pro-Phe-Phe-4-methylcoumarin-7-amide 37°C, pH 8.5 Rattus norvegicus
0.085
-
 D-Pro-Phe-Phe-4-methylcoumarin-7-amide 37°C, pH 8.5 Mus musculus
0.73
-
 o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
 Homo sapiens
0.8
-
 o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
1.49
-
 o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
3.1
-
 o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Homo sapiens
3.18
-
 D-Pro-Phe-Arg-4-methylcoumarin-7-amide 37°C, pH 8.5 Mus musculus
3.2
-
 D-Pro-Phe-Arg-4-methylcoumarin-7-amide 37°C, pH 8.5 Rattus norvegicus
3.27
-
 o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
3.6
-
 D-Pro-Phe-Arg-4-methylcoumarin-7-amide 37°C, pH 8.5 Homo sapiens
5.86
-
 o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
6.6
-
 o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
7
-
 o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
12
-
 o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
12.5
-
 D-Pro-Phe-Phe-4-methylcoumarin-7-amide 37°C, pH 8.5 Homo sapiens
12.7
-
 o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
14.7
-
 o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
18.4
-
 o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Mus musculus
18.7
-
 o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
21.8
-
 o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
-
 Rattus norvegicus
95.3
-
 D-Pro-Phe-Arg-4-methylcoumarin-7-amide 37°C, pH 8.5 Rattus norvegicus