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Literature summary for 3.4.21.35 extracted from
- Biochemical characterization and substrate specificity of rat prostate kallikrein (S3): comparison with tissue kallikrein, tonin and T-kininogenase (1992), Biochim. Biophys. Acta, 1121, 309-316.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antipain | - |
Rattus norvegicus |  |
| benzamidine | - |
Rattus norvegicus | |
| leupeptin | - |
Rattus norvegicus | |
| Soybean trypsin inhibitor | - |
Rattus norvegicus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 14000 | - |
x * 14000 + x * 18000, SDS-PAGE under reducing conditions | Rattus norvegicus |
| 18000 | - |
x * 14000 + x * 18000, SDS-PAGE under reducing conditions | Rattus norvegicus |
| 28000 | - |
x * 28000, SDS-PAGE in absence of a reducing agent | Rattus norvegicus |
| 32000 | - |
x * 32000, K2, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polypeptide + H2O | Rattus norvegicus | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 58fold | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| submandibular gland | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | reaction with prostate enzyme, very low reaction with submandibular enzyme | Rattus norvegicus | ? | - |
? | |
| angiotensinogen + H2O | reaction with prostate enzyme, no reaction with submandibular enzyme | Rattus norvegicus | ? | - |
? | |
| kininogen + H2O | rat low molecular weight kininogen and bovine low molecular weight kininogen, T-kininogen | Rattus norvegicus | kinin + ? | - |
? | |
| polypeptide + H2O | - |
Rattus norvegicus | peptides | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 14000 + x * 18000, SDS-PAGE under reducing conditions | Rattus norvegicus |
| ? | x * 32000, K2, SDS-PAGE | Rattus norvegicus |
| ? | x * 28000, SDS-PAGE in absence of a reducing agent | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
kinin releasing activity, prostate | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 10 | pH 8.0: about 60% of maximal activity, pH 10.0: about 55% of maximal activity, kinin releasing activity, prostate | Rattus norvegicus |
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