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BRENDA support

Literature summary for 3.4.21.35 extracted from

  • Katz, B.A.; Liu, B.; Barnes, M.; Springman, E.B.
    Crystal structure of recombinant human tissue kallikrein at 2.0 A resolution (1998), Protein Sci., 7, 875-885.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme expressed in a deglycosylated form at high levels in Pichia pastoris, structure analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y228A enlarges the S1 pocket Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information Zn2+-dependent small-molecule competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in blood pressure regulation and inflammation processes ?
-
?
polypeptide + H2O Homo sapiens
-
peptides
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
enzyme expressed in a deglycosylated form at high levels in Pichia pastoris Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involved in blood pressure regulation and inflammation processes Homo sapiens ?
-
?
polypeptide + H2O
-
Homo sapiens peptides
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0033
-
Zn2+-dependent small-molecule competitive inhibitor
-
Homo sapiens