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Literature summary for 3.4.21.35 extracted from
- Human tissue kallikrein. II. Isolation and characterization of human salivary kallikrein (1983), Hoppe-Seyler's Z. Physiol. Chem., 364, 425-432.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aprotinin | - |
Homo sapiens |  |
| diisopropyl fluorophosphate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.06 | - |
D-Val-Leu-Arg-p-nitroanilide | - |
Homo sapiens | |
| 0.14 | - |
acetyl-Phe-Arg ethyl ester | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polypeptide + H2O | Homo sapiens | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| salivary gland | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, stable for more than 3 months | Homo sapiens |
| 4°C, stable for 1 month | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-Phe-Arg ethyl ester + H2O | - |
Homo sapiens | acetyl-Phe-Arg + ethanol | - |
? | |
| D-Val-Leu-Arg-p-nitroanilide + H2O | - |
Homo sapiens | D-Val-Leu-Arg + p-nitroaniline | - |
? | |
| kininogen + H2O | high-molecular weight kininogen | Homo sapiens | kinin + ? | - |
? | |
| low-molecular-weight kininogen + H2O | - |
Homo sapiens | kallidin + kinin | - |
? | |
| N-alpha-acetyl-Phe-Arg ethyl ester + H2O | - |
Homo sapiens | N-alpha-acetyl-Phe-Arg + ethanol | - |
? | |
| polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 10 | cleavage of D-Val-Leu-Arg-p-nitroanilide | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00000007 | - |
diisopropyl fluorophosphate | pH 7.2, 25°C | Homo sapiens | |
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