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Literature summary for 3.4.21.35 extracted from
- Isolation of tissue kallikrein in rat spleen by monoclonal antibody-affinity chromatography (1984), Biochim. Biophys. Acta, 801, 244-249.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aprotinin | - |
Rattus norvegicus |  |
| kallikrein antibody | - |
Rattus norvegicus | |
| Soybean trypsin inhibitor | weak | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | secretion | Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38000 | - |
x * 38000, SDS-PAGE under reducing conditions | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polypeptide + H2O | Rattus norvegicus | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spleen | - |
Rattus norvegicus | - |
| urine | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kininogen + H2O | - |
Rattus norvegicus | kinin + ? | - |
? | |
| low-molecular-weight kininogen + H2O | - |
Rattus norvegicus | kallidin + kinin | - |
? | |
| polypeptide + H2O | - |
Rattus norvegicus | peptides | - |
? | |
| Tosyl-Arg methyl ester + H2O | - |
Rattus norvegicus | Tosyl-Arg + methanol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 38000, SDS-PAGE under reducing conditions | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
tosyl-Arg methyl esterase activity | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 10 | pH 8.0: about 35% of maximal activity, pH 10.0: about 70% of maximal activity | Rattus norvegicus |
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