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Literature summary for 3.4.21.35 extracted from

  • Yousef, G.M.; Diamandis, E.P.
    The new human tissue kallikrein gene family: structure, function, and association to disease (2001), Endocr. Rev., 22, 184-204.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Protein C inhibitor cleaves the inhibitor at Arg354-Ser355 without inactivating it; covalent complex formation with K2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kininogen + H2O Homo sapiens best substrate kallidin + kinin heavy chain + kinin light chain
-
?
kininogen + H2O Homo sapiens enzyme is involved in inflammation, sepsis, pancreatitis, bone metabolism, heart disease, renal disease, and cancer through release of kallidin, i.e. Lys-bradykinin kallidin + kinin heavy chain + kinin light chain
-
?
polypeptide + H2O Homo sapiens
-
peptides
-
?
polypeptide + H2O Homo sapiens implicated in processing of growth factrors and peptide hormones peptides
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P06870 gene KLK1
-

Reaction

Reaction Comment Organism Reaction ID
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds substrate binding pocket contains an Asp residue Homo sapiens
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds trypsin-like serine protease Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast lower content Homo sapiens
-
endometrium activity is higher during the middle of the menstrual cycle, possible up-regulation by estrogens Homo sapiens
-
intestine
-
Homo sapiens
-
intestine low content Homo sapiens
-
kidney
-
Homo sapiens
-
neutrophil low content Homo sapiens
-
pancreas
-
Homo sapiens
-
pituitary gland
-
Homo sapiens
-
placenta lower content Homo sapiens
-
prostate gland
-
Homo sapiens
-
prostate gland low content Homo sapiens
-
salivary gland
-
Homo sapiens
-
sweat gland low content Homo sapiens
-
testis lower content Homo sapiens
-
uterus low content Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O
-
Homo sapiens angiotensin
-
?
kininogen + H2O best substrate Homo sapiens kallidin + kinin heavy chain + kinin light chain
-
?
kininogen + H2O enzyme is involved in inflammation, sepsis, pancreatitis, bone metabolism, heart disease, renal disease, and cancer through release of kallidin, i.e. Lys-bradykinin Homo sapiens kallidin + kinin heavy chain + kinin light chain
-
?
low density lipoprotein + H2O
-
Homo sapiens ?
-
?
low-molecular-weight kininogen + H2O
-
Homo sapiens kallidin + kinin kallidin is Lys-bradykinin ?
low-molecular-weight kininogen + H2O cleavage sequence and sites Homo sapiens kallidin + kinin kallidin is Lys-bradykinin ?
polypeptide + H2O
-
Homo sapiens peptides
-
?
polypeptide + H2O implicated in processing of growth factrors and peptide hormones Homo sapiens peptides
-
?
precursor of atrial natriuretic factor + H2O
-
Homo sapiens natriuretic factor
-
?
pro-collagenase + H2O
-
Homo sapiens collagease
-
?
pro-insulin + H2O
-
Homo sapiens insulin + insulin signal peptide
-
?
pro-renin + H2O
-
Homo sapiens renin
-
?
Vasoactive intestinal peptide + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
pancreatic/renal kallikrein
-
Homo sapiens
renal kallikrein
-
Homo sapiens