Cloned (Comment) | Organism |
---|---|
genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Protein C inhibitor | cleaves the inhibitor at Arg354-Ser355 without inactivating it; covalent complex formation with K2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
kininogen + H2O | Homo sapiens | best substrate | kallidin + kinin heavy chain + kinin light chain | - |
? | |
kininogen + H2O | Homo sapiens | enzyme is involved in inflammation, sepsis, pancreatitis, bone metabolism, heart disease, renal disease, and cancer through release of kallidin, i.e. Lys-bradykinin | kallidin + kinin heavy chain + kinin light chain | - |
? | |
polypeptide + H2O | Homo sapiens | - |
peptides | - |
? | |
polypeptide + H2O | Homo sapiens | implicated in processing of growth factrors and peptide hormones | peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P06870 | gene KLK1 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds | substrate binding pocket contains an Asp residue | Homo sapiens | |
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds | trypsin-like serine protease | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | lower content | Homo sapiens | - |
endometrium | activity is higher during the middle of the menstrual cycle, possible up-regulation by estrogens | Homo sapiens | - |
intestine | - |
Homo sapiens | - |
intestine | low content | Homo sapiens | - |
kidney | - |
Homo sapiens | - |
neutrophil | low content | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
pituitary gland | - |
Homo sapiens | - |
placenta | lower content | Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
prostate gland | low content | Homo sapiens | - |
salivary gland | - |
Homo sapiens | - |
sweat gland | low content | Homo sapiens | - |
testis | lower content | Homo sapiens | - |
uterus | low content | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | - |
Homo sapiens | angiotensin | - |
? | |
kininogen + H2O | best substrate | Homo sapiens | kallidin + kinin heavy chain + kinin light chain | - |
? | |
kininogen + H2O | enzyme is involved in inflammation, sepsis, pancreatitis, bone metabolism, heart disease, renal disease, and cancer through release of kallidin, i.e. Lys-bradykinin | Homo sapiens | kallidin + kinin heavy chain + kinin light chain | - |
? | |
low density lipoprotein + H2O | - |
Homo sapiens | ? | - |
? | |
low-molecular-weight kininogen + H2O | - |
Homo sapiens | kallidin + kinin | kallidin is Lys-bradykinin | ? | |
low-molecular-weight kininogen + H2O | cleavage sequence and sites | Homo sapiens | kallidin + kinin | kallidin is Lys-bradykinin | ? | |
polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
polypeptide + H2O | implicated in processing of growth factrors and peptide hormones | Homo sapiens | peptides | - |
? | |
precursor of atrial natriuretic factor + H2O | - |
Homo sapiens | natriuretic factor | - |
? | |
pro-collagenase + H2O | - |
Homo sapiens | collagease | - |
? | |
pro-insulin + H2O | - |
Homo sapiens | insulin + insulin signal peptide | - |
? | |
pro-renin + H2O | - |
Homo sapiens | renin | - |
? | |
Vasoactive intestinal peptide + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pancreatic/renal kallikrein | - |
Homo sapiens |
renal kallikrein | - |
Homo sapiens |