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Literature summary for 3.4.21.34 extracted from
- Human plasma kallikrein (1981), Biochem. J., 193, 187-192.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aprotinin | - |
Homo sapiens |  |
| leupeptin | - |
Homo sapiens | |
| Pro-Phe-Arg-CH2Cl | - |
Homo sapiens | |
| Soybean trypsin inhibitor | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22000 | - |
1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains | Homo sapiens |
| 28000 | - |
1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains | Homo sapiens |
| 36000 | - |
1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains | Homo sapiens |
| 86000 | - |
? * 86000, SDS-PAGE, kallikrein II | Homo sapiens |
| 88000 | - |
? * 88000, SDS-PAGE, kallikrein I | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kininogen + H2O | Homo sapiens | cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
kallikrein I, kallikrein II | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kininogen + H2O | cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation | Homo sapiens | ? | - |
? | |
| Nalpha-Benzoyl-L-Arg ethyl ester + H2O | - |
Homo sapiens | Nalpha-Benzoyl-L-Arg + ethanol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | ? * 86000, SDS-PAGE, kallikrein II | Homo sapiens |
| More | ? * 88000, SDS-PAGE, kallikrein I | Homo sapiens |
| trimer | 1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains | Homo sapiens |
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