Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor XIIa | - |
Mus musculus | |
factor XIIa | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | enzyme inhibition can decrease blood-brain barrier damage and cell invasion during neuroinflammation and may offer a strategy for the treatment of multiple sclerosis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor XII + H2O | Mus musculus | - |
activated factor XII | - |
? | |
factor XII + H2O | Homo sapiens | - |
activated factor XII | - |
? | |
kininogen + H2O | Mus musculus | - |
bradykinin + fragments of kininogen | - |
? | |
kininogen + H2O | Homo sapiens | - |
bradykinin + fragments of kininogen | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor XII + H2O | - |
Mus musculus | activated factor XII | - |
? | |
factor XII + H2O | - |
Homo sapiens | activated factor XII | - |
? | |
kininogen + H2O | - |
Mus musculus | bradykinin + fragments of kininogen | - |
? | |
kininogen + H2O | - |
Homo sapiens | bradykinin + fragments of kininogen | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme levels are markedly enhanced in active central nervous system lesions of multiple sclerosis patients | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency leads to decreased immune cell trafficking in the course of neuroinflammation | Mus musculus |
malfunction | enzyme deficiency leads to decreased immune cell trafficking in the course of neuroinflammation | Homo sapiens |
physiological function | the enzyme modulates endothelial cell function in a protease-activated receptor-2-dependent manner, leading to an up-regulation of the cellular adhesion molecules intercellular adhesion molecule 1 and vascular cell adhesion molecule 1, thereby amplifying leukocyte trafficking. The enzyme is an important direct regulator of blood-brain barrier integrity | Mus musculus |
physiological function | the enzyme modulates endothelial cell function in a protease-activated receptor-2-dependent manner, leading to an up-regulation of the cellular adhesion molecules intercellular adhesion molecule 1 and vascular cell adhesion molecule 1, thereby amplifying leukocyte trafficking. The enzyme is an important direct regulator of blood-brain barrier integrity | Homo sapiens |