Literature summary for 3.4.21.34 extracted from

Li, C.; Voos, K.M.; Pathak, M.; Hall, G.; McCrae, K.R.; Dreveny, I.; Li, R.; Emsley, J.
Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI (2019), J. Thromb. Haemost., 17, 759-770 .

Search for more literature for 3.4.21.34

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Drosophila S2 cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop vapor diffusion method, using 0.1 M carboxylic acids, 0.1 M HEPES/MOPS pH 7.5, 12.5% (v/v) 2-methyl-2,4-pentanediol, 12.5% (w/v) PEG1000, 12.5% (w/v) PEG3350 and a drop containing 0.1 M carboxylic acids, 0.1 M Tris/Bicine pH 8.5, 20% (w/v) PEG 500 MME	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
S559A	active site mutant	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
factor XII + H2O	Homo sapiens	-	activated factor XII	-	?
kininogen + H2O	Homo sapiens	-	bradykinin + fragments of kininogen	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P03952	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-Sepharose column chromatography and Superdex S200 gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
factor XII + H2O	-	Homo sapiens	activated factor XII	-	?
kininogen + H2O	-	Homo sapiens	bradykinin + fragments of kininogen	-	?

Synonyms

Synonyms	Comment	Organism
KLKb1	-	Homo sapiens
PKA	-	Homo sapiens

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Release 2023.1 (January 2023)