Literature summary for 3.4.21.34 extracted from

Teufel, D.P.; Bennett, G.; Harrison, H.; van Rietschoten, K.; Pavan, S.; Stace, C.; Le Floch, F.; Van Bergen, T.; Vermassen, E.; Barbeaux, P.; Hu, T.T.; Feyen, J.H.M.; Vanhove, M.
Stable and long-lasting, novel bicyclic peptide plasma kallikrein inhibitors for the treatment of diabetic macular edema (2018), J. Med. Chem., 61, 2823-2836 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
bicyclic peptide Ac-CiS1F2[Aze]3Y4[HArg]5Cii[Ala(PsiCH2-NH)]6H7Q8D9L10Ciii	-	Rattus norvegicus
bicyclic peptide Ac-CiS1W2P3A4R5CiiL6H7Q8D9L10Ciii	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
kininogen + H2O	Rattus norvegicus	-	bradykinin + fragments of kininogen	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
kininogen + H2O	-	Rattus norvegicus	bradykinin + fragments of kininogen	-	?

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Release 2023.1 (January 2023)