Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor XIIa | - |
Homo sapiens | |
prolylcarboxypeptidase | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
high molecular weight kininogen + H2O | Homo sapiens | - |
bradykinin + fragments of kininogen | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | D-Pro-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
high molecular weight kininogen + H2O | - |
Homo sapiens | bradykinin + fragments of kininogen | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 86000-88000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Plasma prekallikrein | precursor | Homo sapiens |
PPK | precursor | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme sensitizes human platelets by binding to platelet integrins through its KGD (Lys488-Gly489-Asp490 and Lys556-Gly557-Asp558) and KGE (Lys509-Gly510-Glu511) motifs and to cleave PAR-1. These actions enhance platelet activation by subthreshold doses of ADP leading to Ca2+ mobilization, MAPK-related signaling, and ATP release | Homo sapiens |