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Literature summary for 3.4.21.34 extracted from
- Plasma kallikrein: the bradykinin-producing enzyme (2013), Thromb. Haemost., 110, 399-407.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| factor XIIa | - |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aprotinin | - |
Homo sapiens |  |
| C1INH | - |
Homo sapiens | |
| ecallantide | DX-88 | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 79500 | - |
x * 79500, prekallikrein, calculated from amino acid sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor B + H2O | Homo sapiens | - |
factor Bb + ? | - |
? | |
| factor XII + H2O | Homo sapiens | - |
factor XIIa + ? | - |
? | |
| high-molecular-weight kininogen + H2O | Homo sapiens | - |
bradykinin + fragments of kininogen | - |
? | |
| pro-urokinase type plasminogen activator + H2O | Homo sapiens | - |
urokinase type plasminogen activator + ? | - |
? | |
| Prorenin + H2O | Homo sapiens | - |
Renin + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor B + H2O | - |
Homo sapiens | factor Bb + ? | - |
? | |
| factor XII + H2O | - |
Homo sapiens | factor XIIa + ? | - |
? | |
| high-molecular-weight kininogen + H2O | - |
Homo sapiens | bradykinin + fragments of kininogen | - |
? | |
| pro-urokinase type plasminogen activator + H2O | - |
Homo sapiens | urokinase type plasminogen activator + ? | - |
? | |
| Prorenin + H2O | - |
Homo sapiens | Renin + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 79500, prekallikrein, calculated from amino acid sequence | Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | calculated from amino acid sequence | - |
8.59 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme drives multiple proteolytic reaction cascades in the cardiovascular system such as the intrinsic pathway of coagulation, the kallikrein-kinin system, the fibrinolytic system, the renin-angiotensin system and the alternative complement pathway | Homo sapiens |
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Release 2023.1 (January 2023)
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