Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Pro-Phe-Arg-4-nitroanilide + H2O | - |
Homo sapiens | D-Pro-Phe-Arg + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
plasma KK | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | plasma kallikrein directly activates G protein-coupled protease-activated receptors (PAR) 1 and 2. Plasma kallikrein stimulates ADAM (a disintegrin and metalloprotease) 17 activity via a PAR1/2 receptor-dependent mechanism, leading sequentially to release of the endogenous ADAM17 substrates, amphiregulin and tumor necrosis factor-alpha, metalloprotease-dependent transactivation of epidermal growth factor receptors, and metalloprotease and epidermal growth factor receptor-dependent ERK1/2 activation | Homo sapiens |