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Literature summary for 3.4.21.34 extracted from
- Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery (2008), Expert. Opin. Biol. Ther., 8, 1187-1199.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ecallantide | also called DX-88, C305H442N86O91S8, potent and specific inhibitor of plasma kallikrein | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor XII + H2O | Homo sapiens | - |
activated factor XII + ? | - |
? |  |
| kininogen + H2O | Homo sapiens | - |
bradykinin + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor XII + H2O | - |
Homo sapiens | activated factor XII + ? | - |
? | |
| kininogen + H2O | - |
Homo sapiens | bradykinin + ? | - |
? | |
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