Literature summary for 3.4.21.34 extracted from

Lima, A.R.; Alves, F.M.; Angelo, P.F.; Andrade, D.; Blaber, S.I.; Blaber, M.; Juliano, L.; Juliano, M.A.
S(1) and S(2) subsite specificities of human plasma kallikrein and tissue kallikrein 1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen (2008), Biol. Chem., 389, 1487-1494.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
kininogen + H2O	Homo sapiens	the presence of S at P1' position for bradykinin release by human plasma kallikrein appears to be essential	bradykinin + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2 + H2O	-	Homo sapiens	2-aminobenzoyl-MISLMK + RPPGFSPFRSSRI-NH2	-	?
kininogen + H2O	the presence of S at P1' position for bradykinin release by human plasma kallikrein appears to be essential	Homo sapiens	bradykinin + ?	-	?

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Release 2023.1 (January 2023)