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Literature summary for 3.4.21.34 extracted from

  • Schmaier, A.H.
    Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system (2008), Int. Immunopharmacol., 8, 161-165.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.34

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular kallikrein Homo sapiens
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XII + H2O Homo sapiens proteolytic activation activated factor XII + ?
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 ?
high-molecular-weight kininogen + H2O Homo sapiens
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 high-molecular-weight kinin + bradykinin bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
additional information Homo sapiens the enzyme is part of the plasma kallikrein/kinin system that consists of the protein factor XII, prekallikrein, and high-molecular-weight kininogen, intravascular assembly of the plasma kallikrein/kinin system, overview, it acts as a surface-activated coagulation system arising when blood or plasma interacts with artificial surfaces, kallikrein is involved in development of arterial thrombosis, mechanisms, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the plasma kallikrein/kinin system has two mechanisms for its activation: one that is dependent and another independent of factor XII, the latter is realized by autoactivation on a negatively charged artificial or biologic surface or by serine protease prolylcarboxypeptidase, a PK activator on endothelial cell surfaces, while factor XIIa performs proteolytic activation of the zymogen prekallikrein, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information intravascular assembly of the plasma kallikrein/kinin system Homo sapiens
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plasma kallikrein Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XII + H2O proteolytic activation Homo sapiens activated factor XII + ?
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 ?
high-molecular-weight kininogen + H2O
-
 Homo sapiens high-molecular-weight kinin + bradykinin bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
additional information the enzyme is part of the plasma kallikrein/kinin system that consists of the protein factor XII, prekallikrein, and high-molecular-weight kininogen, intravascular assembly of the plasma kallikrein/kinin system, overview, it acts as a surface-activated coagulation system arising when blood or plasma interacts with artificial surfaces, kallikrein is involved in development of arterial thrombosis, mechanisms, overview Homo sapiens ?
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 ?