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Literature summary for 3.4.21.34 extracted from

  • Sulikowski, T.; Bauer, B.A.; Patston, P.A.
    alpha1-Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1 (2002), Protein Sci., 11, 2230-2236.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.34

Application

Application Comment Organism
pharmacology design of specific inhibitors for proteases like plasma kallikrein, but not protein C, to diminish the complement hydrolysis and coagulation during sepsis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-proteinase inhibitor-Leu-Gly-Arg mutant of serpin alpha1-proteinase inhibitor with exchange at P3, P2 and P1 position, fast complexing, inhibition kinetics Homo sapiens
alpha1-proteinase inhibitor-Pro-Phe-Arg mutant of serpin alpha1-proteinase inhibitor with exchange at P3, P2 and P1 position, inhibition kinetics Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in inflammatory processes via hydrolysis of complement ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Pro-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens D-Pro-Phe-Arg + 4-nitroaniline
-
 ir
additional information involved in inflammatory processes via hydrolysis of complement Homo sapiens ?
-
 ?