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Literature summary for 3.4.21.34 extracted from
- Immunolocalization of plasma kallikrein in human brain (2000), Metab. Brain Dis., 15, 315-323.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activation of prekallikrein to active kallikrein proceeds via hydrolysis of the bond Arg371-Ile372 leading to formation of 2 chains connected via 2 disulfide bonds | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | ependymal cells | Homo sapiens | 5829 | - |
| soluble | prekallikrein, plasma | Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33000 | - |
x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE | Homo sapiens |
| 55000 | - |
x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE | Homo sapiens |
| 88000 | - |
x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kininogen + H2O | Homo sapiens | enzyme is a cofactor in blood coagulation and modulates inflammation through release of bradykinin | bradykinin + fragment of kininogen | - |
ir |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | prekallikrein expression | Homo sapiens | - |
| blood | prekallikrein expression | Homo sapiens | - |
| brain | prekallikrein expression | Homo sapiens | - |
| brain stem | prekallikrein expression | Homo sapiens | - |
| cerebral cortex | prekallikrein expression | Homo sapiens | - |
| endothelium | prekallikrein expression | Homo sapiens | - |
| ependymal cell | in sections of hypothalamus and spinalcord, prekallikrein expression | Homo sapiens | - |
| epithelial cell | prekallikrein expression | Homo sapiens | - |
| fibre tract | of pons, hipocampus, and medulla, prekallikrein expression | Homo sapiens | - |
| fibroblast | prekallikrein expression | Homo sapiens | - |
| heart | prekallikrein expression | Homo sapiens | - |
| hepatocyte | prekallikrein | Homo sapiens | - |
| hippocampus | some fibre tracts, prekallikrein expression | Homo sapiens | - |
| hypothalamus | prekallikrein expression | Homo sapiens | - |
| kidney | prekallikrein expression | Homo sapiens | - |
| leukocyte | prekellikrein expression | Homo sapiens | - |
| liver | prekallikrein, secretion into blood circulation | Homo sapiens | - |
| lung | prekallikrein expression | Homo sapiens | - |
| medulla oblongata | some fibre tracts, prekallikrein expression | Homo sapiens | - |
| midbrain | prekallikrein expression | Homo sapiens | - |
| additional information | no expression of prekallikrein in the choroid plexus or the cerebellum | Homo sapiens | - |
| neuron | prekallikrein expression | Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| pituitary gland | secretory cells, prekallikrein expression | Homo sapiens | - |
| placenta | prekallikrein expression | Homo sapiens | - |
| plasma | prekallikrein expression | Homo sapiens | - |
| pons | some fibre tracts, prekallikrein expression | Homo sapiens | - |
| spinal cord | prekallikrein expression | Homo sapiens | - |
| thalamus | prekallikrein expression | Homo sapiens | - |
| trachea | prekallikrein expression | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity in pancreas and brain | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kininogen + H2O | - |
Homo sapiens | bradykinin + fragment of kininogen | - |
? | |
| kininogen + H2O | enzyme is a cofactor in blood coagulation and modulates inflammation through release of bradykinin | Homo sapiens | bradykinin + fragment of kininogen | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PK | - |
Homo sapiens |
| PPK | i.e. plasma prekallikrein | Homo sapiens |
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