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Literature summary for 3.4.21.27 extracted from

  • Zucker, M.; Seligsohn, U.; Yeheskel, A.; Mor-Cohen, R.
    An allosteric disulfide bond is involved in enhanced activation of factor XI by protein disulfide isomerase (2016), J. Thromb. Haemost., 14, 2202-2211 .
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Protein disulfide isomerase reduction of the enzyme by protein disulfide isomerase enhances its cleavage activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in baby hamster kidney cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C147S inactive Homo sapiens
C321S the mutant shows wild type activity Homo sapiens
C482S the mutant shows 1.45fold enhanced activity as compared with the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor IX + H2O Homo sapiens
-
activated factor IX + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor IX + H2O
-
Homo sapiens activated factor IX + ?
-
?
S2366 + H2O
-
Homo sapiens L-pyroGlu-L-Pro-L-Arg + 4-nitroaniline
-
?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
FXI
-
Homo sapiens