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Literature summary for 3.4.21.27 extracted from

  • Renne, T.; Oschatz, C.; Seifert, S.; Mueller, F.; Antovic, J.; Karlman, M.; Benz, P.M.
    Factor XI deficiency in animal models (2009), J. Thromb. Haemost., 7 Suppl 1, 79-83.
    View publication on PubMed
Search for more literature for 3.4.21.27

Activating Compound

Activating Compound Comment Organism Structure
activated factor XII activates its substrate FXI Homo sapiens
Factor XII FXI is activated by factor XII during ischemia reperfusion injury and within the growing thrombus according to the classical intrinsic pathway cascade Mus musculus
thrombin
-
 Mus musculus
thrombin thrombin generated early in coagulation by the tissue factor pathway activates FXI creating a positive feedback loop that sustains coagulation following inactivation of the factor VIIa/tissue factor complex by tissue factor pathway inhibitor Homo sapiens

Application

Application Comment Organism
medicine therapeutically targeting FXI may offer a strategy for preventing or treating arterial thrombosis that is not associated with the high rate of hemorrhage that accompanies many currently used anticoagulants. Pharmacological FXI inhibitors may be beneficial in septic disease Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 2 * 80000 Mus musculus
80000
-
 2 * 80000 Homo sapiens
160000
-
-
 Mus musculus
160000
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Didelphis sp.
-
-
-
Felis catus
-
-
-
Homo sapiens P03951
-
-
Mus musculus
-
-
-
Ornithorhynchus anatinus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-
blood plasma
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
homodimer 2 * 80000 Mus musculus
homodimer 2 * 80000 Homo sapiens

Synonyms

Synonyms Comment Organism
factor XI
-
 Mus musculus
factor XI
-
 Canis lupus familiaris
factor XI
-
 Felis catus
factor XI
-
 Ornithorhynchus anatinus
factor XI
-
 Didelphis sp.
factor XI
-
 Homo sapiens
FXI
-
 Mus musculus
FXI
-
 Canis lupus familiaris
FXI
-
 Felis catus
FXI
-
 Ornithorhynchus anatinus
FXI
-
 Didelphis sp.
FXI
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus is predominantly, if not exclusively, expressed in the liver up

General Information

General Information Comment Organism
malfunction addition of murine FXI to human FXI deficient plasma rescues the prolonged activated partial thromboplastin time, but with a slightly reduced activity compared with the human protein. FXI-/- mice are healthy, fertile, and phenotypically indistinguishable from wild-type animals. Mating between heterozygous FXI+/- mice follows the expected Mendelian ratio arguing against an association of FXI deficiency and increased risk of abortion. Plasma from FXI null mice show a severely prolonged activated partial thromboplastin time compared with wild-type animals. Bleeding times in adult FXI-/- mice are indistinguishable from wild-type animals, suggesting that FXI does not significantly contribute to fibrin formation. Formation of thrombi is severely defective in FXI-/- mice. Both fibrin deposition and platelet accumulation are reduced in FXI null mice compared with wild-type. FXI deficiency increases survival and reduces leukocyte infiltration and coagulopathy Mus musculus
malfunction FXI deficient humans suffer from mild hemorrhage (hemophilia C), which is characterized by trauma or soft tissue-related hemorrhage, primarily involving tissues with high fibrinolytic activity. Bleeding severity in FXI deficiency is not associated with FXI plasma levels. Addition of murine FXI to human FXI deficient plasma rescues the prolonged activated partial thromboplastin time, but with a slightly reduced activity compared with the human protein Homo sapiens
malfunction probably due to inbreeding, presence of FXI deficiency Canis lupus familiaris
malfunction probably due to inbreeding, presence of FXI deficiency Felis catus
physiological function 78% homology to human FXI at the protein level. FXI is critical for fibrin formation in vivo. FXI may have additional functions in regulation of inflammation or tissue repair distinct from its role in coagulation Mus musculus
physiological function presence of a single precursor of FXI and plasma kallikrein, appearance of FXI among early tetrapods Ornithorhynchus anatinus
physiological function the opossum genome has two distinct genes for both FXI and plasma kallikrein, indicating that the gene duplication event leading to separate factors occurred early in mammalian evolution Didelphis sp.