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Literature summary for 3.4.21.27 extracted from

  • Ogawa, T.; Verhamme, I.M.; Sun, M.F.; Bock, P.E.; Gailani, D.
    Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX (2005), J. Biol. Chem., 280, 23523-23530.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.27

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin
-
 Homo sapiens
factor fIX factor IX Homo sapiens
factor fIXai factor IXai Homo sapiens
p-aminobenzamidine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
 factor fIX FXIa Homo sapiens
233
-
 L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide FXIa Homo sapiens
352
-
 L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide fXIaCD Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 2 * 80000, SDS-PAGE Homo sapiens
160000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
antibody-affinity chromatography by using the calcium-dependent anti-human fIX monoclonal IgG SB 249417 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor fIX + H2O factor IX Homo sapiens ?
-
 ?
L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide + H2O
-
 Homo sapiens L-pyroglutamyl-L-prolyl-L-arginine + p-nitroaniline
-
 ?
methyl-sulfonyl-D-cyclo-hexyl-glycyl-glycyl-arginine-p-nitroanilide + H2O
-
 Homo sapiens methyl-sulfonyl-D-cyclo-hexyl-glycyl-glycyl-arginine + p-nitroaniline
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 80000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
factor XIa
-
 Homo sapiens
factor XIa catalytic domain
-
 Homo sapiens
FXIa
-
 Homo sapiens
fXIaCD
-
 Homo sapiens
protease factor XIa
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.49
-
 factor fIX fXIa Homo sapiens
67
-
 L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide fXIaCD Homo sapiens
117
-
 L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide fXIa Homo sapiens