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Literature summary for 3.4.21.27 extracted from
- Factor XIa dimer in the activation of factor IX (2005), Biochemistry, 44, 10416-10422.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Dextran sulfate | 33nM | Homo sapiens | |
| FXIIa | - |
Homo sapiens | |
| thrombin | 1nM, activating function only in presence of dextran sulfate | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | blood coagulation | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK293 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| FXI/G326C | mutant of FXI with Gly326 residue mutated to Cys326 | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.357 | - |
S-2366 | FXIa | Homo sapiens |  |
| 0.384 | - |
S-2366 | mutant FXIa/G326C | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 72626 | - |
1 * 72626, mutant FXI/G326C, SDS-PAGE | Homo sapiens |
| 72630 | - |
mutant FXI/G326C, SDS-PAGE | Homo sapiens |
| 73210 | - |
2 * 73210, FXI, SDS-PAGE | Homo sapiens |
| 146400 | - |
FXI, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| affinity chromatography with antibody 5F7, gel filtration | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor IX + H2O | - |
Homo sapiens | factor IXa + ? | - |
? | |
| L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide + H2O | - |
Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginine + p-nitroaniline | - |
? | |
| N-benzoyl-L-arginine-p-nitroanilide + H2O | - |
Homo sapiens | N-benzoyl-L-arginine + p-nitroaniline | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 73210, FXI, SDS-PAGE | Homo sapiens |
| monomer | 1 * 72626, mutant FXI/G326C, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| activated factor XI | FXIa | Homo sapiens |
| factor XI | FXI | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Homo sapiens |
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Release 2023.1 (January 2023)
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