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Literature summary for 3.4.21.27 extracted from

  • Jin, L.; Pandey, P.; Babine, R.E.; Weaver, D.T.; Abdel-Meguid, S.S.; Strickler, J.E.
    Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors (2005), Acta Crystallogr. Sect. D, D61, 1418-1425.
    View publication on PubMed
Search for more literature for 3.4.21.27

Application

Application Comment Organism
medicine antithrombosis therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris strain X-33 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzamidine weak inhibitor of FXIa Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 method not mentioned Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
SP-Sepharose column chromatography, Heparin HiTrap column chromatography and Superdex 75 column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide + H2O
-
 Homo sapiens L-pyroglutamyl-L-prolyl-L-arginine + p-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
activated factor XIa
-
 Homo sapiens
factor XI
-
 Homo sapiens
FXI
-
 Homo sapiens
FXIa
-
 Homo sapiens
recombinant human FXI370-607
-
 Homo sapiens
rhFXI370-607
-
 Homo sapiens