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Literature summary for 3.4.21.27 extracted from

  • Peek, M.; Moran, P.; Mendoza, N.; Wickramasinghe, D.; Kirchhofer, D.
    Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa (2002), J. Biol. Chem., 277, 47804-47809.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-HGF + H2O Homo sapiens the enzyme may regulate processes that involve the HGF/c-Met pathway, such as tissue repair and angiogenesis ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-HGF + H2O HGF i. e. hepatocyte growth factor, pro-HGF is processed by cleavage at two sites: Arg494-Val 495 and Arg424-His425. Cleavage at Arg424-His425 is independent of a prior cleavage at the primary kinetically preferred Arg 494-Val495 site. The mutant substrate pro-HGF(R424A/R494E) is completely resistant to cleavage Homo sapiens ?
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 ?
pro-HGF + H2O the enzyme may regulate processes that involve the HGF/c-Met pathway, such as tissue repair and angiogenesis Homo sapiens ?
-
 ?