Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-phenyl-butanoyl-L-prolyl-2(S)-cyanopyrrolidine | KYP-2047 | Homo sapiens | |
4-phenyl-butanoyl-L-prolyl-2(S)-cyanopyrrolidine | KYP-204, 0.1 mM and 0.5 mM concentrations significantly inhibit enzyme activity in tissue homogenate | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymosin beta4 + H2O | Homo sapiens | - |
acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
umbilical vein endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the recombinant prolyl oligopeptidase is not able to cleave whole 43-mer thymosin beta4, while it is effective at hydrolyzing somatostatin-28 (1-12) | Rattus norvegicus | ? | - |
? | |
N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin | - |
? | |
somatostatin-28 (1-12) + H2O | - |
Rattus norvegicus | ? | - |
? | |
thymosin beta4 + H2O | - |
Homo sapiens | acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro + ? | - |
? | |
thymosin beta4 + H2O | prolyl oligopeptidase is a second-step enzyme in the release of acetyl-N-Ser-Asp-Lys-Pro from thymosin beta4 and has autoregulatory effect in the first step | Rattus norvegicus | acetyl-N-Ser-Asp-Lys-Pro + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
POP | - |
Homo sapiens |
POP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | prolyl oligopeptidase is a second-step enzyme in the release of acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro from thymosin beta4, and it has autoregulatory effect in the first step | Homo sapiens |
physiological function | prolyl oligopeptidase has a pro-angiogenic role via the release of acetyl-N-Ser-Asp-Lys-Pro from its precursor thymosin beta4 | Rattus norvegicus |
physiological function | prolyl oligopeptidase with thymosin beta4 significantly induces angiogenesis of human umbilical vein endothelial cells. Prolyl oligopeptidase has a pro-angiogenic role via the release of acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro from its precursor thymosin beta4 | Homo sapiens |