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Literature summary for 3.4.21.26 extracted from

  • Sakaguchi, M.; Matsuda, T.; Matsumura, E.; Yoshimoto, T.; Takaoka, M.
    Prolyl oligopeptidase participates in cell cycle progression in a human neuroblastoma cell line (2011), Biochem. Biophys. Res. Commun., 409, 693-698.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-AI cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-({4-[2-(E)-styrylphenoxy]butanoyl}-L-4-hydroxyprolyl)-thiazolidine SUAM-14746, selective prolyl oligopeptidase inhibitor Homo sapiens
benzyloxycarbonyl-thioprolyl-thioprolinal specific inhibitor of prolyl oligopeptidase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose column chromatography and Mono Q 5/50 GL column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
NB-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O
-
Homo sapiens N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
POP
-
Homo sapiens
post-proline cleaving enzyme
-
Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition or knockdown of prolyl oligopeptidase leads to suppression of NB-1 cell growth, and the effect is accompanied by G0/G1 arrest Homo sapiens
physiological function prolyl oligopeptidase participates in cell cycle progression in human NB-1 neuroblastoma cells Homo sapiens