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Literature summary for 3.4.21.26 extracted from

  • Braber, S.; Koelink, P.J.; Henricks, P.A.; Jackson, P.L.; Nijkamp, F.P.; Garssen, J.; Kraneveld, A.D.; Blalock, J.E.; Folkerts, G.
    Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown (2011), Am. J. Physiol. Lung Cell Mol. Physiol., 300, L255-L265.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung highly expressed in lung tissue of cigarette smoke-exposed mice Mus musculus
-
macrophage
-
 Mus musculus
-
neutrophil
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O
-
 Mus musculus ?
-
 ?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Gly-L-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
prolyl endopeptidase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus prolyl endopeptidas activity is 2fold elevated in the lungs of cigarette smoke-exposed mice up

General Information

General Information Comment Organism
metabolism prolyl endopeptidase is involved in collagen breakdown Mus musculus
physiological function cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase Mus musculus