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Literature summary for 3.4.21.26 extracted from

  • Comellas, G.; Kaczmarska, Z.; Tarragó, T.; Teixidó, M.; Giralt, E.
    Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates (2009), PLoS ONE, 4, e6222.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Z-proline prolinal
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
more than 90% purity Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AbzGFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa AbzGFGP + FGF(p-NO2)A-NH2
-
?
H-(O2Oc)2-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
H-Abz-GFGP-OH + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
H-Abz-GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
H-F(p-NO2)GFGP-OH + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)-HMBA-PEGA + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)-HMBA-PEGA
-
?
H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)-NH2
-
?
H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)2-HMBA-PEGA + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)2-HMBA-PEGA
-
?
H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)2-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)2-NH2
-
?
H-F(p-NO2)GFGPFGK(Abz)A-HMBA-PEGA + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-HMBA-PEGA
-
?
H-F(p-NO2)GFGPFGK(Abz)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-NH2
-
?
H-FGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
H-K(Abz)-GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
H-O2Oc-K(Abz)-GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
PEGA(O2Oc)2-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
PEGA-K(ABz)-GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
PEGA-O2Oc-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?

Synonyms

Synonyms Comment Organism
prolyl oligopeptidase
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Sus scrofa

General Information

General Information Comment Organism
malfunction enzyme associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders Sus scrofa