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Literature summary for 3.4.21.26 extracted from

  • Rea, D.; Fueloep, V.
    Structure-function properties of prolyl oligopeptidase family enzymes (2006), Cell Biochem. Biophys., 44, 349-365.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in open conformation Novosphingobium capsulatum
enzyme with bound inhibitor Myxococcus xanthus

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-proline-prolinal specific inhibition Homo sapiens
benzyloxycarbonyl-proline-prolinal specific inhibition Myxococcus xanthus
benzyloxycarbonyl-proline-prolinal specific inhibition Novosphingobium capsulatum
benzyloxycarbonyl-proline-prolinal specific inhibition Pyrococcus furiosus
benzyloxycarbonyl-proline-prolinal specific inhibition Trypanosoma cruzi
fluoxetine an antidepressant Homo sapiens
additional information inhibitor binding structure Myxococcus xanthus
Valproic acid an antimanic drug Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted enzyme Trypanosoma cruzi
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen + H2O Trypanosoma cruzi the pathogen POP degrades host collagen and fibronectin, facilitating cell invasion, selective inhibitors for trypanosome POP block parasite entry into cells ?
-
?
Fibronectin + H2O Trypanosoma cruzi the pathogen POP degrades host collagen and fibronectin, facilitating cell invasion, selective inhibitors for trypanosome POP block parasite entry into cells ?
-
?
additional information Homo sapiens POP activity levels are lowered in different stages of depression, whereas activity is increased in patients with mania and schizophrenia, the antidepressant fluoxetine and the antimanic drug valproic acid both restore POP activity to normal levels ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Myxococcus xanthus
-
-
-
Novosphingobium capsulatum Q9ZNM8
-
-
Pyrococcus furiosus
-
-
-
Trypanosoma cruzi
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides catalytic mechanism, structure-function relationship, the enzyme contains a Ser-Asp-His catalytic triad, substrate specificity and binding structure,overview Homo sapiens
Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides catalytic mechanism, structure-function relationship, the enzyme contains a Ser-Asp-His catalytic triad, substrate specificity and binding structure,overview Pyrococcus furiosus
Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides catalytic mechanism, structure-function relationship, the enzyme contains a Ser-Asp-His catalytic triad, substrate specificity and binding structure,overview Trypanosoma cruzi
Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides catalytic mechanism, structure-function relationship, the enzyme contains a Ser-Asp-His catalytic triad, substrate specificity and binding structure,overview Myxococcus xanthus
Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides catalytic mechanism, structure-function relationship, the enzyme contains a Ser-Asp-His catalytic triad, substrate specificity and binding structure,overview Novosphingobium capsulatum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O the pathogen POP degrades host collagen and fibronectin, facilitating cell invasion, selective inhibitors for trypanosome POP block parasite entry into cells Trypanosoma cruzi ?
-
?
Collagen + H2O host-derived substrate Trypanosoma cruzi ?
-
?
Fibronectin + H2O the pathogen POP degrades host collagen and fibronectin, facilitating cell invasion, selective inhibitors for trypanosome POP block parasite entry into cells Trypanosoma cruzi ?
-
?
Fibronectin + H2O host-derived substrate Trypanosoma cruzi ?
-
?
additional information POP activity levels are lowered in different stages of depression, whereas activity is increased in patients with mania and schizophrenia, the antidepressant fluoxetine and the antimanic drug valproic acid both restore POP activity to normal levels Homo sapiens ?
-
?
additional information the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, and hydrolyse several peptide hormones and neuropeptides in vitro Homo sapiens ?
-
?
additional information the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, general acid/base catalysis is the rate-limiting step, overview Pyrococcus furiosus ?
-
?
additional information the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, overview Trypanosoma cruzi ?
-
?
additional information the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, overview Myxococcus xanthus ?
-
?
additional information the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, the loops connecting the peptidase and propeller domains act like a hinge, holding the structure together as the domains move apart, creating a large opening, overview Novosphingobium capsulatum ?
-
?

Synonyms

Synonyms Comment Organism
More the enzyme is a member of the prolyl oligopeptidase family, subfamily S9a Homo sapiens
More the enzyme is a member of the prolyl oligopeptidase family, subfamily S9a Pyrococcus furiosus
More the enzyme is a member of the prolyl oligopeptidase family, subfamily S9a Trypanosoma cruzi
More the enzyme is a member of the prolyl oligopeptidase family, subfamily S9a Myxococcus xanthus
More the enzyme is a member of the prolyl oligopeptidase family, subfamily S9a Novosphingobium capsulatum
POP
-
Homo sapiens
POP
-
Pyrococcus furiosus
POP
-
Trypanosoma cruzi
POP
-
Myxococcus xanthus
POP
-
Novosphingobium capsulatum