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Literature summary for 3.4.21.26 extracted from

  • Jarho, E.M.; Wallen, E.A.; Christiaans, J.A.; Forsberg, M.M.; Venaelaeinen, J.I.; Maennistoe, P.T.; Gynther, J.; Poso, A.
    Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions (2005), J. Med. Chem., 48, 4772-4782.
    View publication on PubMed
Search for more literature for 3.4.21.26

Inhibitors

Inhibitors Comment Organism Structure
(2R)-1-(1-[[3-(azepan-1-ylcarbonyl)phenyl]carbonyl]-L-prolyl)pyrrolidine-2-carbonitrile 50% inhibition at 4.6 nM Sus scrofa
(2R)-1-(1-[[4-(pyrrolidin-1-ylcarbonyl)phenyl]carbonyl]-L-prolyl)pyrrolidine-2-carbonitrile 50% inhibition at 1.6 nM Sus scrofa
(2R)-1-[1-(4-azepan-1-yl-4-oxobutanoyl)-L-prolyl]pyrrolidine-2-carbonitrile 50% inhibition at 0.76 nM Sus scrofa
(2R)-1-[1-(4-oxo-4-pyrrolidin-1-ylbutanoyl)-L-prolyl]pyrrolidine-2-carbonitrile 50% inhibition at 2.9 nM Sus scrofa
(2R)-1-[1-(5-azepan-1-yl-3,3-dimethyl-5-oxopentanoyl)-L-prolyl]pyrrolidine-2-carbonitrile 50% inhibition at 0.39 nM Sus scrofa
(2R)-1-[1-(5-azepan-1-yl-5-oxopentanoyl)-L-prolyl]pyrrolidine-2-carbonitrile 50% inhibition at 1.2 nM Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa P23687
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sus scrofa
-