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Literature summary for 3.4.21.22 extracted from

  • Thompson, A.R.
    Structure, function and molecular defects of factor IX (1986), Blood, 67, 565-572.
    View publication on PubMed
Search for more literature for 3.4.21.22

Activating Compound

Activating Compound Comment Organism Structure
factor VIII in modified form, established in the activation of factor X Homo sapiens
Phospholipid increases the activation of factor X Homo sapiens
platelet factor 3 in vivo, established in the activation of factor X Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
antithrombin III a nonspecific protein inhibitor, in presence of heparin, this forms a stable or covalent-like intermediate with the factor IXa Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ factor IX activation is the first calcium-dependent reaction in intrinsic system clotting Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Homo sapiens a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
endothelium factor IXa binds specifically to the surface of endothelial cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor X + H2O a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa Homo sapiens ?
-
 ?
factor X + H2O
-
 Homo sapiens factor Xa activated form ?