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Literature summary for 3.4.21.22 extracted from

  • Wakabayashi, H.; Fay, P.J.
    Replacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXa (2013), J. Biol. Chem., 288, 31289-31297.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Factor VIIIa factor VIIIa functions as a cofactor for factor IXa in the conversion of zymogen factor X to factor Xa. Factor IXa binding affinity for factor VIIIa is significantly reduced in the presence of GMA8011 (about 10fold) Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Factor X + H2O Homo sapiens
-
Factor Xa + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor X + H2O
-
Homo sapiens Factor Xa + ?
-
?

Synonyms

Synonyms Comment Organism
factor IXa
-
Homo sapiens
FIXa
-
Homo sapiens