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Literature summary for 3.4.21.22 extracted from

  • Branchini, A.; Campioni, M.; Mazzucconi, M.; Biondo, F.; Mari, R.; Bicocchi, M.; Bernardi, F.; Pinotti, M.
    Replacement of the Y450 (c234) phenyl ring in the carboxyl-terminal region of coagulation factor IX causes pleiotropic effects on secretion and enzyme activity (2013), FEBS Lett., 587, 3249-3253.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
Y450C the mutant shows about 5% activity compared to the wild type enzyme Homo sapiens
Y450F the mutant shows about 25% activity compared to the wild type enzyme Homo sapiens
Y450S the mutant shows about 5% activity compared to the wild type enzyme Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6000
-
 x * 6000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Factor X + H2O Homo sapiens
-
 Factor Xa + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor X + H2O
-
 Homo sapiens Factor Xa + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 6000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
factor IX
-
 Homo sapiens
FIX
-
 Homo sapiens