Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor IX-specific antibodies | antibosies specific for human factor I, e.g. 198A1, 198B3, and 224F3, enhance the factor IXa activity mimicking the stimulatory effect of FVIIIa, and thus can replace FVIIIa as cofactor in the FX activation reaction, overview | Homo sapiens | |
Factor VIIIa | binds to the activated factor IX and enhances the activation of factor X by several orders of magnitude | Homo sapiens | |
Phospholipid | the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+ | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+ | Homo sapiens | |
Na+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | Homo sapiens | the enzyme acts in complex with factor VIIIa, FVIIIa deficiency causes the bleeding disorder hemaphilia A | activated factor X + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | from plasma | Homo sapiens | - |
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | the enzyme acts in complex with factor VIIIa, FVIIIa deficiency causes the bleeding disorder hemaphilia A | Homo sapiens | activated factor X + ? | - |
? | |
factor X + H2O | the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+ | Homo sapiens | activated factor X + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activated coagulation factor IX | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | 7.4 | assay at | Homo sapiens |