Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.22 extracted from

  • Bedsted, T.; Swanson, R.; Chuang, Y.J.; Bock, P.E.; Bjork, I.; Olson, S.T.
    Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites (2003), Biochemistry, 42, 8143-8152.
    View publication on PubMed
Search for more literature for 3.4.21.22

Activating Compound

Activating Compound Comment Organism Structure
Factor VIIIa
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
antithrombin almost no inhibition in the absence of heparin, strong acceleration of the inhibition rate in the presence of heparin and physiologic levels of Ca2+ Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 4-8fold allosteric activation at 5 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Homo sapiens
-
 factor Xa
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-cyclohexylglycyl-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens D-cyclohexylglycyl-Gly-Arg + 7-amino-4-methylcoumarin
-
 ?
D-cyclohexylglycyl-Gly-Arg-p-nitroanilide + H2O
-
 Homo sapiens D-cyclohexylglycyl-Gly-Arg + p-nitroaniline
-
 ?
factor X + H2O
-
 Homo sapiens factor Xa
-
 ?