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Literature summary for 3.4.21.20 extracted from

  • Fu, Z.; Thorpe, M.; Alemayehu, R.; Roy, A.; Kervinen, J.; de Garavilla, L.; Abrink, M.; Hellman, L.
    Highly selective cleavage of cytokines and chemokines by the human mast cell chymase and neutrophil cathepsin G (2017), J. Immunol., 198, 1474-1483 .
    View publication on PubMed
Search for more literature for 3.4.21.20

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CD40L + H2O Homo sapiens low activity ?
-
 ?
human recombinant B-cell activating factor + H2O Homo sapiens low activity ?
-
 ?
interleukin-15 + H2O Homo sapiens
-
 ?
-
 ?
interleukin-17A + H2O Homo sapiens low activity ?
-
 ?
interleukin-18 + H2O Homo sapiens
-
 ?
-
 ?
interleukin-2 + H2O Homo sapiens low activity ?
-
 ?
interleukin-21 + H2O Homo sapiens low activity ?
-
 ?
interleukin-22 + H2O Homo sapiens low activity ?
-
 ?
interleukin-24 + H2O Homo sapiens low activity ?
-
 ?
interleukin-3 + H2O Homo sapiens
-
 ?
-
 ?
interleukin-31 + H2O Homo sapiens efficient substrate ?
-
 ?
interleukin-33 + H2O Homo sapiens
-
 ?
-
 ?
interleukin-6 + H2O Homo sapiens efficient substrate ?
-
 ?
interleukin-7 + H2O Homo sapiens efficient substrate ?
-
 ?
membrane-bound stem cell factor + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens the extended cleavage sites for the enzyme contain about 8 amino acids, and cleavage normally occurs after an aromatic amino acid (phenylalanine, tyrosine and tryptophan or leucine) in the P1 substrate position ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CD40L + H2O low activity Homo sapiens ?
-
 ?
human recombinant B-cell activating factor + H2O low activity Homo sapiens ?
-
 ?
interleukin-15 + H2O
-
 Homo sapiens ?
-
 ?
interleukin-17A + H2O low activity Homo sapiens ?
-
 ?
interleukin-18 + H2O
-
 Homo sapiens ?
-
 ?
interleukin-2 + H2O low activity Homo sapiens ?
-
 ?
interleukin-21 + H2O low activity Homo sapiens ?
-
 ?
interleukin-22 + H2O low activity Homo sapiens ?
-
 ?
interleukin-24 + H2O low activity Homo sapiens ?
-
 ?
interleukin-3 + H2O
-
 Homo sapiens ?
-
 ?
interleukin-31 + H2O efficient substrate Homo sapiens ?
-
 ?
interleukin-33 + H2O
-
 Homo sapiens ?
-
 ?
interleukin-6 + H2O efficient substrate Homo sapiens ?
-
 ?
interleukin-7 + H2O efficient substrate Homo sapiens ?
-
 ?
membrane-bound stem cell factor + H2O
-
 Homo sapiens ?
-
 ?
additional information the extended cleavage sites for the enzyme contain about 8 amino acids, and cleavage normally occurs after an aromatic amino acid (phenylalanine, tyrosine and tryptophan or leucine) in the P1 substrate position Homo sapiens ?
-
 ?
additional information no activity with interleukin-4, interleukin-5, or interleukin-10 Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
physiological function the enzyme functions in regulating excessive inflammation Homo sapiens