Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cathepsin G inhibitor I | - |
Homo sapiens | |
cathepsin G inhibitor I | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cadherin + H2O | Homo sapiens | - |
? | - |
? | |
cadherin + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08311 | - |
- |
Mus musculus | P28293 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
neutrophil | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cadherin + H2O | - |
Homo sapiens | ? | - |
? | |
cadherin + H2O | - |
Mus musculus | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | both pharmacologic inhibition of cathepsin G and its congenital absence prolonge the time for platelet thrombus to form in ferric chloride-injured mouse mesenteric arterioles. In a vaso-occlusive model of ischemic stroke, inhibition of cathepsin G and its congenital absence improves cerebral blood flow, reduces histologic brain injury, and improves neurobehavioral outcome | Mus musculus |
physiological function | neutrophil cathepsin G is a physiologic modulator of platelet thrombus formation in vivo | Homo sapiens |
physiological function | neutrophil cathepsin G is a physiologic modulator of platelet thrombus formation in vivo | Mus musculus |